CUSIP No. 57886P103
|
|
Page 2 of 14
|
|||
|
|
|
|||
1
|
NAMES OF REPORTING PERSONS
Larry N. Feinberg
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) ☐
(b) ☒
|
||||
3
|
SEC USE ONLY
|
||||
4
|
SOURCE OF FUNDS (See Instructions)
PF
|
||||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)
|
||||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States
|
||||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
|
7
|
SOLE VOTING POWER
191,875*
|
|||
8
|
SHARED VOTING POWER
2,027,925**
|
||||
9
|
SOLE DISPOSITIVE POWER
191,875*
|
||||
10
|
SHARED DISPOSITIVE POWER
2,027,925**
|
||||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,219,800***
|
||||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)
|
||||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
8.67%****
|
||||
14
|
TYPE OF REPORTING PERSON (See Instructions)
IN
|
CUSIP No. 57886P103
|
|
Page 3 of 14
|
|||
|
|
|
|||
1
|
NAMES OF REPORTING PERSONS
Oracle Associates, LLC
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) ☐
(b) ☒
|
||||
3
|
SEC USE ONLY
|
||||
4
|
SOURCE OF FUNDS (See Instructions)
N/A
|
||||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)
|
||||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
|
7
|
SOLE VOTING POWER
-0-
|
|||
8
|
SHARED VOTING POWER
1,966,025*
|
||||
9
|
SOLE DISPOSITIVE POWER
-0-
|
||||
10
|
SHARED DISPOSITIVE POWER
1,966,025*
|
||||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,966,025*
|
||||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)
|
||||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
7.68%**
|
||||
14
|
TYPE OF REPORTING PERSON (See Instructions)
OO
|
CUSIP No. 57886P103
|
|
Page 4 of 14
|
|||
|
|
|
|||
1
|
NAMES OF REPORTING PERSONS
Oracle Partners, LP
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) ☐
(b) ☒
|
||||
3
|
SEC USE ONLY
|
||||
4
|
SOURCE OF FUNDS (See Instructions)
OO
|
||||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)
|
||||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
|
7
|
SOLE VOTING POWER
-0-
|
|||
8
|
SHARED VOTING POWER
1,447,350*
|
||||
9
|
SOLE DISPOSITIVE POWER
-0-
|
||||
10
|
SHARED DISPOSITIVE POWER
1,447,350*
|
||||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,447,350*
|
||||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)
|
||||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
5.66%**
|
||||
14
|
TYPE OF REPORTING PERSON (See Instructions)
PN
|
CUSIP No. 57886P103
|
|
Page 5 of 14
|
|||
|
|
|
|||
1
|
NAMES OF REPORTING PERSONS
Oracle Institutional Partners, LP
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) ☐
(b) ☒
|
||||
3
|
SEC USE ONLY
|
||||
4
|
SOURCE OF FUNDS (See Instructions)
N/A
|
||||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)
|
||||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
|
7
|
SOLE VOTING POWER
-0-
|
|||
8
|
SHARED VOTING POWER
235,246*
|
||||
9
|
SOLE DISPOSITIVE POWER
-0-
|
||||
10
|
SHARED DISPOSITIVE POWER
235,246*
|
||||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
235,246*
|
||||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)
|
||||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
0.92%**
|
||||
14
|
TYPE OF REPORTING PERSON (See Instructions)
PN
|
CUSIP No. 57886P103
|
|
Page 6 of 14
|
|||
|
|
|
|||
1
|
NAMES OF REPORTING PERSONS
Oracle Ten Fund Master, LP
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) ☐
(b) ☒
|
||||
3
|
SEC USE ONLY
|
||||
4
|
SOURCE OF FUNDS (See Instructions)
N/A
|
||||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)
|
||||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
|
7
|
SOLE VOTING POWER
-0-
|
|||
8
|
SHARED VOTING POWER
283,429*
|
||||
9
|
SOLE DISPOSITIVE POWER
-0-
|
||||
10
|
SHARED DISPOSITIVE POWER
283,429*
|
||||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
283,429*
|
||||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)
|
||||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.11%**
|
||||
14
|
TYPE OF REPORTING PERSON (See Instructions)
OO
|
CUSIP No. 57886P103
|
|
Page 7 of 14
|
|||
|
|
|
|||
1
|
NAMES OF REPORTING PERSONS
Oracle Investment Management, Inc.
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) ☐
(b) ☒
|
||||
3
|
SEC USE ONLY
|
||||
4
|
SOURCE OF FUNDS (See Instructions)
N/A
|
||||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)
|
||||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
|
7
|
SOLE VOTING POWER
-0-
|
|||
8
|
SHARED VOTING POWER
2,017,025*
|
||||
9
|
SOLE DISPOSITIVE POWER
-0-
|
||||
10
|
SHARED DISPOSITIVE POWER
2,017,025*
|
||||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,017,025*
|
||||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)
|
||||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
7.88%**
|
||||
14
|
TYPE OF REPORTING PERSON (See Instructions)
OO
|
CUSIP No. 57886P103
|
|
Page 8 of 14
|
|||
|
|
|
|||
1
|
NAMES OF REPORTING PERSONS
Oracle Investment Management, Inc. Employees’ Retirement Plan
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) ☐
(b) ☒
|
||||
3
|
SEC USE ONLY
|
||||
4
|
SOURCE OF FUNDS (See Instructions)
OO
|
||||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)
|
||||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
|
7
|
SOLE VOTING POWER
-0-
|
|||
8
|
SHARED VOTING POWER
51,000*
|
||||
9
|
SOLE DISPOSITIVE POWER
-0-
|
||||
10
|
SHARED DISPOSITIVE POWER
51,000*
|
||||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
51,000*
|
||||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)
|
||||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
0.20%**
|
||||
14
|
TYPE OF REPORTING PERSON (See Instructions)
PN
|
CUSIP No. 57886P103
|
|
Page 9 of 14
|
|||
|
|
|
|||
1
|
NAMES OF REPORTING PERSONS
The Feinberg Family Foundation
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) ☐
(b) ☒
|
||||
3
|
SEC USE ONLY
|
||||
4
|
SOURCE OF FUNDS (See Instructions)
N/A
|
||||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)
|
||||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON WITH
|
7
|
SOLE VOTING POWER
-0-
|
|||
8
|
SHARED VOTING POWER
10,900*
|
||||
9
|
SOLE DISPOSITIVE POWER
-0-
|
||||
10
|
SHARED DISPOSITIVE POWER
10,900*
|
||||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
10,900*
|
||||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)
|
||||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
0.04%**
|
||||
14
|
TYPE OF REPORTING PERSON (See Instructions)
PN
|
Item 5. |
Interest in Securities of the Issuer.
|
(i) |
Oracle Partners may be deemed to beneficially own 1,447,350 American Depositary Shares, representing 5.66% of the outstanding Ordinary Shares;
|
(ii) |
Oracle Ten Fund may be deemed to beneficially own 283,429 American Depositary Shares, representing 1.11% of the outstanding Ordinary Shares;
|
(iii) |
Oracle Institutional Partners may be deemed to beneficially own 235,246 American Depositary Shares, representing 0.92% of the outstanding Ordinary Shares;
|
(iv) |
Oracle Associates, due to its relationship with Oracle Partners, Oracle Institutional Partners and Oracle Ten Fund, may be deemed to beneficially own 1,966,025 American Depositary Shares, representing 7.68% of the outstanding Ordinary Shares;
|
(v) |
the Foundation may be deemed to beneficially own 10,900 American Depositary Shares, representing 0.04% of the outstanding Ordinary Shares;
|
(vi) |
the Retirement Plan may be deemed to beneficially own 51,000 American Depositary Shares, representing 0.20% of the outstanding Ordinary Shares;
|
(vii) |
Investment Manager, due to its relationship with Oracle Partners, Oracle Institutional Partners, Oracle Ten Fund and the Retirement Plan, may be deemed to beneficially own 2,017,025 American Depositary Shares, representing 7.88% of the outstanding Ordinary Shares;
|
(viii) |
Mr. Feinberg, due to his respective relationships with the other Reporting Persons, may be deemed to beneficially own 2,219,800 American Depositary Shares, representing 8.67% of the outstanding Ordinary Shares,
|
Transacting Party
|
Date
|
Transaction Type
|
Number of ADSs
|
Price Per ADS
(excluding commissions) |
Oracle Partners
|
08/17/2017
|
Open Market Sale
|
2,650
|
$38.41
|
Oracle Partners
|
08/22/2017
|
Open Market Sale
|
14,800
|
$38.40
|
Oracle Partners
|
08/23/2017
|
Open Market Sale
|
7,504
|
$38.16
|
Oracle Partners
|
09/19/2017
|
Open Market Sale
|
8,000
|
$46.99
|
Oracle Partners
|
09/25/2017
|
Open Market Sale
|
25,000
|
$48.71
|
Oracle Institutional Partners
|
08/17/2017
|
Open Market Sale
|
445
|
$38.41
|
Oracle Institutional Partners
|
08/22/2017
|
Open Market Sale
|
2,456
|
$38.40
|
Oracle Institutional Partners
|
09/19/2017
|
Open Market Sale
|
2,000
|
$46.99
|
Oracle Institutional Partners
|
09/25/2017
|
Open Market Sale
|
5,000
|
$48.71
|
Oracle Ten Fund
|
08/17/2017
|
Open Market Sale
|
600
|
$38.41
|
Oracle Ten Fund
|
08/22/2017
|
Open Market Sale
|
3,100
|
$38.40
|
Oracle Ten Fund
|
09/25/2017
|
Open Market Sale
|
5,000
|
$48.71
|
Foundation
|
08/24/2017
|
Open Market Sale
|
2,700
|
$38.29
|
Foundation
|
08/25/2017
|
Open Market Sale
|
1,700
|
$38.35
|
Retirement
|
08/24/2017
|
Open Market Sale
|
5,300
|
$38.31
|
Retirement
|
08/25/2017
|
Open Market Sale
|
8,700
|
$38.34
|
Larry N. Feinberg
|
08/23/2017
|
Open Market Sale
|
10,000
|
$38.16
|
Larry N. Feinberg
|
09/25/2017
|
Open Market Sale
|
10,000
|
$48.71
|
Dated: October 19, 2017
|
ORACLE PARTNERS, L.P.
By: ORACLE ASSOCIATES, LLC, its general partner
By: /s/ Larry N. Feinberg
Name: Larry N. Feinberg Title: Managing Member |
Dated: October 19, 2017
|
ORACLE INSTITUTIONAL PARTNERS, L.P.
By: ORACLE ASSOCIATES, LLC, its general partner
By: /s/ Larry N. Feinberg
Name: Larry N. Feinberg Title: Managing Member |
Dated: October 19, 2017
|
ORACLE TEN FUND MASTER, LP
By: ORACLE ASSOCIATES, LLC, its general partner
By: /s/ Larry N. Feinberg
Name: Larry N. Feinberg
Title: Managing Member
|
Dated: October 19, 2017
|
ORACLE ASSOCIATES, LLC
By: /s/ Larry N. Feinberg
Name: Larry N. Feinberg Title: Managing Member |
Dated: October 19, 2017
|
ORACLE INVESTMENT MANAGEMENT, INC.
By: /s/ Larry N. Feinberg
Name: Larry N. Feinberg Title: President and Director |
Dated: October 19, 2017
|
THE FEINBERG FAMILY FOUNDATION
By: /s/ Larry N. Feinberg
Name: Larry N. Feinberg Title: Trustee |
Dated: October 19, 2017
|
ORACLE INVESTMENT MANAGEMENT, INC.
EMPLOYEES’ RETIREMENT PLAN
By: /s/ Larry N. Feinberg
Name: Larry N. Feinberg Title: Trustee |
Dated: October 19, 2017
|
LARRY N. FEINBERG
By: /s/ Larry N. Feinberg
|